If you’re like most people, then no one has ever told you about glycation. Affecting Collagen and Elastin fibers, glycation is now well recognised to be a leading cause of accelerated skin aging.
Glucose is the sugar your body uses as its main source of fuel. If not metabolized properly, glucose can bind to your skin’s collagen and elastin fibers, forming abnormal chemical bridges that cause tissue damage. This process, called glycation, causes your skin to become rigid and lose elasticity.
Glycation also impairs your skin’s ability to regenerate, which leads to skin laxity, cracking, thinning, redness, and inability to self-repair.
The genes that make up your Wrinkling (A.G.E.) score play a key role in skin Glycation. They are responsible for controlling serum glucose levels, energy intake and energy release.
Having variations in these genes can alter the functioning of normal glucose levels and energy metabolism. While glucose is a vital cellular fuel, if not completely metabolised by the body Glycation can occur, leading way to wrinkling, dryness and laxity.
PPARg & ADRB
Glycation is a process where sugar molecules attach themselves to proteins or fats without the help of enzymes. Once these sugar molecules are attached, they can interact with other proteins and form advanced glycation end products (AGEs). The real problem of glycation is the glycated proteins that stagnate in the body and in particular the dermis. They are fertile ground for the multiplication of free radicals and the appearance of oxidative stress, which is particularly harmful to the skin. Scientific studies have shown that PPARg and ADRB3 gene variants are significantly associated with glycation and skin ageing.
Glycation damages collagen and elastin, two proteins that keep skin looking plump and youthful. When these proteins are damaged, the skin becomes thin, wrinkled, and less elastic. In other words, glycation can speed up the aging process. Glycation also increases inflammation, which can lead to acne breakouts and other skin problems.
As your skin ages these supportive fibers—which are responsible for the appearance and texture of your skin—lose their supportive network as a result of glycation.
COLLAGEN IS THE PRINCIPLE STRUCTURAL PROTEIN THAT HOLDS THE SKIN TOGETHER.
Collagen is just one of thousands of different proteins in the body. The most abundant protein is collagen. In fact, collagen makes up more than one third of all protein in the body and about 75% of the skin.
GLUCOSE IS THE BODY’S PRIME SOURCE OF FUEL FOR GENERATING ENERGY. IT IS A TYPE OF SUGAR THAT COMES FROM DIGESTING CARBOHYDRATES INTO A CHEMICAL THAT WE CAN EASILY CONVERT TO ENERGY.
But glucose has its dark side. If not properly metabolised Glucose can bind tightly to proteins and form abnormal chemical bridges that progressively damage tissue elasticity. This process is referred to as Glycation.
ELASTIN IS A PROTEIN FOUND IN CONNECTIVE TISSUE THAT IS ELASTIC. IN THE SKIN, ELASTIN HELPS KEEP FLEXIBILITY BY PROVIDING A BOUNCE-BACK REACTION IF SKIN IS PULLED OR PINCHED.
Enough elastin in the skin means that the skin will return to its normal shape after a pull or a pinch. It also helps keep skin smooth as it stretches to accommodate normal activities like flexing a muscle or opening and closing the mouth to talk or eat.
GLYCATION OCCURS WHEN EXCESS BODILY GLUCOSE MOLECULES LINK TO THE SKIN’S COLLAGEN AND ELASTIN FIBERS.
This cross-linking can form chemical bridges between these proteins. Glycated fibers can become rigid, less elastic and have reduced regenerative ability, which can lead to damage such as laxity, cracking and thinning skin.